Faculty Research 1990 - 1999

Title

Osteochondrodystrophy (ocd): a new autosomal recessive mutation in the mouse.

Document Type

Article

Publication Date

1991

Keywords

Bone-and-Bones: pa, Crosses-Genetic, Dwarfism: ge, pa, Female, Genes-Recessive, Linkage-(Genetics), Male, Mice, Mutation, Phenotype, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J Hered 1991 Mar-Apr; 82(2):140-4.

Grant

CA34196

Abstract

Osteochondrodystrophy (ocd) is a new autosomal recessive mouse mutation characterized by a short, slightly domed head, reduced body size, disproportionately shortened long bones of the legs, supination of the forefeet, and short thickened tail. Histologically, the epiphyses are thinner than normal. The columnar organization of the proliferative zone of cartilage is disorderly, with pleomorphic and occasionally necrotic chondrocytes. Osteochondrodystrophy has been mapped to a position near the centromere of mouse chromosome (Chr) 19.

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