Faculty Research 1990 - 1999

Title

T cells facilitate Brugia malayi development in TCRalpha(null) mice.

Document Type

Article

Publication Date

1999

Keywords

Animal, Brugia-malayi, Elephantiasis-Filarial, Host-Parasite-Relations, Immunocompetence, Immunocompromised-Host, Mice, Mice-Inbred-C57BL, Mice-SCID, Phenotype, Receptors-Antigen-T-Cell-alpha-beta, T-Lymphocytes: im

JAX Source

Exp Parasitol 1999 Sep;93(1):55-7

Grant

AI39705/AI/NIAID, AI42362/AI/NIAID, AI30389/AI/NIAID

Abstract

The host-parasite interactions of Brugia malayi in mice are complex and multifactorial. In order to study the role of T cells in early B. malayi development, we infected TCRalpha(null) mice, which retain a population of CD4+ TCRbeta+ cells and TCRbeta(null) mice, which lack all TCRalphabeta(+) T cells. TCRalpha(null) mice were permissive to L4 larval and adult worm development but TCRbeta(null) mice were not. Depletion of the CD4(+) T cells in the former abrogated the permissive phenotype. It appears that the CD4(+) TCRbeta(+) T cells that have been described in TCRalpha(null) mice may facilitate early B. malayi development. These data are similar to our earlier demonstration of the role of NK cells in facilitating worm growth in SCID mice. Copyright 1999 Academic Press.

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