Faculty Research 1990 - 1999

Title

Skeletal dysplasias, growth retardation, reduced postnatal survival, and impaired fertility in mice lacking the SNF2/SWI2 family member ETL1.

Document Type

Article

Publication Date

1999

Keywords

Bone-and-Bones, DNA-Binding-Proteins, Fertility, Fetal-Development, Gene-Expression-Regulation-Developmental, Growth-Disorders, Mice, Mice-Knockout, Mutation, SUPPORT-U-S-GOVT-P-H-S, Transcription-Factors

JAX Source

Mech Dev 1999 Jul;85(1-2):73-83

Grant

CA80234/CA/NCI, CA34196/CA/NCI

Abstract

The mouse Etl1 gene encodes a nuclear protein belonging to the rapidly growing SNF2/SWI2 family. Members of this family are related to helicases and nucleic-acid-dependent ATPases and have functions in essential cellular processes such as transcriptional regulation, maintenance of chromosome stability and various aspects of DNA repair. The ETL1 protein is expressed from the two-cell stage onwards, throughout embryogenesis in a dynamic pattern with particularly high levels in the thymus, epithelia and the nervous system and in most adult tissues. As a first step to address the role of ETL1 in cells and during development, we inactivated the gene by homologous recombination. ES cells and mice lacking

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