Faculty Research 1990 - 1999

Title

Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear.

Document Type

Article

Publication Date

1999

Keywords

Animal, Cochlea, Gene-Expression-Regulation-Developmental, In-Situ-Hybridization, Labyrinth, Membrane-Proteins, Mice, Mice-Knockout, Proteins, SUPPORT-U-S-GOVT-NON-P-H-S

JAX Source

Mech Dev 1999 Jun; 84(1-2):169-72.

Abstract

The Notch signalling pathway is thought to play a key part in controlling the production of sensory hair cells in the vertebrate inner ear via lateral inhibition; but there is disagreement as to which Notch ligands are expressed in hair cells as they develop. We show, using a mouse Delta1:LacZ knock-in as a reporter, that nascent hair cells, but not their neighbours, express Delta1. Expression of Serrate1 (Jagged1), meanwhile becomes restricted to the supporting cells of each sensory patch. Delta1 is also expressed: (a) at early stages, at the site of otic neurogenesis; and (b) in scattered cells of the endolymphatic sac, as is Serrate1.

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