Faculty Research 1990 - 1999

Title

Expression of mouse mammary tumor virus envelope protein does not prevent superinfection in vivo or in vitro.

Document Type

Article

Publication Date

1999

Keywords

Blotting-Western, Cell-Line, DNA-Viral, Female, Mammae, Mammary-Neoplasms-Experimental, Mammary-Tumor-Viruses-Mouse, Mice, Mice-Inbred-C3H, Mice-Transgenic, Proviruses, Recombinant-Proteins, Retroviridae-Infections, Superinfection, SUPPORT-U-S-GOVT-P-H-S, Transfection, Transgenes, Tumor-Virus-Infections, Viral-Envelope-Proteins

JAX Source

Virology 1999 Oct; 263(2):418-26.

Grant

T30CA09140/CA/NCI, CA45954/CA/NCI, CA73746/CA/NCI

Abstract

Inbred mice expressing endogenous mouse mammary tumor virus envelope proteins can be infected with exogenous virus, and the mammary tumors that develop in these mice usually have many proviruses integrated in their genomes, indicating that this virus is not subject to receptor interference. We show here that transgenic mice expressing an exogenous mouse mammary tumor virus (C3H) envelope protein can still be infected with this virus. Moreover, cultured mammary gland cells expressing the mouse mammary tumor virus (C3H) envelope protein can be superinfected with pseudotyped viruses bearing that same protein. Thus cellular expression of the mouse mammary tumor virus envelope protein does not block superinfection in vivo or in vitro. Copyright 1999 Academic Press.

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