Faculty Research 1990 - 1999

Title

Vestibular responses to linear acceleration are absent in otoconia-deficient C57BL/6JEi-het mice.

Document Type

Article

Publication Date

1999

Keywords

Animal, Evoked-Potentials, Evoked-Potentials-Auditory-Brain-Stem, Mice, Mice-Inbred-C57BL, Mice-Mutant-Strains, Mutation, Otolithic-Membrane, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Vestibule

JAX Source

Hear Res 1999 Sep; 135(1-2):56-60.

Grant

HD24374/HD/NICHD

Abstract

Vestibular evoked potentials (VsEPs) were measured in normal mice and in mice homozygous for the head tilt mutation (het/het, abbr. het). The het mice lack otoconia, the inertial mass critical for natural stimulation of inner ear gravity receptors. Our findings demonstrate that vestibular neural responses to pulsed linear acceleration are absent in het mice. The results: (1) confirm that adequate sensory stimuli fail to activate gravity receptors in the het model; and (2) serve as definitive evidence that far-field vestibular responses to pulsed linear acceleration depend critically on otolith end organs. The C57BL/6JEi-het mouse may be an excellent model of gravity receptor sensory deprivation.

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