Faculty Research 1990 - 1999

Title

Organogenic role of B lymphocytes in mucosal immunity.

Document Type

Article

Publication Date

1999

Keywords

B-Lymphocytes, Cell-Count, Genes-Immunoglobulin, IgM, Immunity-Mucosal, Lymphocyte-Transformation, Mammary-Tumor-Viruses-Mouse, Mice, Mice-Inbred-Strains, Mice-Knockout, Mice-Transgenic, Microscopy-Electron-Scanning, Peyer's-Patches, Retroviridae-Infections, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes, Tumor-Virus-Infections

JAX Source

Science 1999 Dec 3;286(5446):1965-8

Grant

CA65795/CA/NCI, DK53561/DK/NIDDK, CA34196/CA/NCI

Abstract

Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.

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