Faculty Research 1990 - 1999

Title

Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice.

Document Type

Article

Publication Date

1999

Keywords

Asthma, Bronchial-Hyperreactivity, Bronchial-Provocation-Tests, Bronchoconstrictor-Agents, Chromosome-Mapping, Chromosomes, Genotype, Linkage-(Genetics), Male, Methacholine-Chloride, Mice, Mice-Inbred-A, Mice-Inbred-C3H, Quantitative-Trait, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Am J Physiol 1999 Dec; 277(6 PT 1):L1118-23.

Grant

HL36110/HL/NHLBI

Abstract

Quantitative trait locus (QTL) mapping was used to identify chromosomal regions contributing to airway hyperresponsiveness in mice. Airway responsiveness to methacholine was measured in A/J and C3H/HeJ parental strains as well as in progeny derived from crosses between these strains. QTL mapping of backcross [(A/J x C3H/HeJ) x C3H/HeJ] progeny (n = 137-227 informative mice for markers tested) revealed two significant linkages to loci on chromosomes 6 and 7. The QTL on chromosome 6 confirms the previous report by others of a linkage in this region in the same genetic backgrounds; the second QTL, on chromosome 7, represents a novel locus. In addition, we obtained suggestive evidence for linkage (logarithm of odds ratio = 1.7) on chromosome 17, which lies in the same region previously identified in a cross between A/J and C57BL/6J mice. Airway responsiveness in a cross between A/J and C3H/HeJ mice is under the control of at least two major genetic loci, with evidence for a third locus that has been previously implicated in an A/J and C57BL/6J cross; this indicates that multiple genetic factors control the expression of this phenotype.

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