Faculty Research 1990 - 1999

Title

Apoptotic and effector pathways in autoimmunity.

Authors

A V. Chervonsky

Document Type

Article

Publication Date

1999

Keywords

Apoptosis, Autoimmune-Diseases, Human, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Curr Opin Immunol 1999 Dec; 11(6):684-8.

Abstract

Programmed cell death is an important anti-autoimmune mechanism used to delete autoreactive lymphocytes and to limit the spread both of viral infections and of tissue damage caused by immune responses. However, in autoimmune diseases, activation of programmed cell death by effector mechanisms that are similar to the normal immune response leads to augmented destruction of the targeted tissues.

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