Faculty Research 1990 - 1999

Title

Immunological mutants of the mouse.

Document Type

Article

Publication Date

1991

Keywords

Autoimmunity: ge, Disease-Models-Animal, Immunity: ge, Mice, Mice-Mutant-Strains: im, Mice-SCID: im, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Am J Anat 1991 Jul; 191(3):303-11.

Grant

CA20408, A130389

Abstract

Mutations at more than 30 loci in mice have been shown to cause deleterious effects on the immune system. Immunologic defects caused by certain of these mutations are determined at the level of hematopoietic progenitor cells or at the level of hematopoietic cell-stromal cell interactions. The immunological mutants described in this paper serve as experimental tools with which to increase our understanding of the development and regulation of the mammalian immune system.

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