Faculty Research 1990 - 1999

Title

Synergism of obesity genes with hepatic steroid sulfotransferases to mediate diabetes in mice.

Document Type

Article

Publication Date

1991

Keywords

Blotting-Northern, Diabetes-Mellitus-Experimental, Female, Liver, Mice, Mice-Inbred-C57BL, Obesity, Sex-Characteristics, Sulfotransferases, Support-U, S, -Gov't-P, H, S

JAX Source

Diabetes 1991 Oct; 40(10):1360-3.

Grant

DK17631, GM40440

Abstract

Sulfotransferases controlling the intrahepatic ratio of actve obesity mutation will be diabetogenic in C57BL/KsJ female mice. Three unlinked genes (diabetes [db], obese [ob], and fat [fat]) all produced comparable obesity in C57BL/KsJ females, but only the fat mutation was not diabetogenic. The fat gene was incapable of eliciting virilizing changes in hepatic sulfotransferase activity, whereas both db and ob accelerated estrogen and suppressed androgen sulfation. Northern-blot analysis confirmed anomalous suppression of hepatic androgen sulfotransferase transcription in db and ob but not fat females. These findings suggest the utility of obesity genes in analyzing the interaction between hyperandrogenism, hyperinsulinemia, and diabetes.

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