Faculty Research 1990 - 1999

Title

Genes for epilepsy mapped in the mouse.

Document Type

Article

Publication Date

1991

Keywords

Chromosome-Mapping, Crosses-Genetic, Disease-Susceptibility: ge, Epilepsy: ge, Female, Male, Mice, Mice-Inbred-Strains, Mice-Neurologic-Mutants: ge, Recombination-Genetic, Seizures: ge, Software, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Science 1991 Aug 9; 253(5020):669-73.

Grant

NS23355

Abstract

The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.

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