Faculty Research 1990 - 1999
Genetic maps of mouse chromosome 17 including 12 new anonymous DNA loci and 25 anchor loci.
Document Type
Article
Publication Date
1991
Keywords
Chromosome-Mapping, Crosses-Genetic, DNA: ge, Genetic-Markers, Mice, Mice-Inbred-C57BL, Muridae, Recombination-Genetic, Restriction-Fragment-Length-Polymorphisms, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S
First Page
78
Last Page
89
JAX Source
Genomics 1991 Jan;9(1):78-89
Grant
HG00189, GM39821, GM11800
Abstract
An interspecific backcross between lab mice and Mus spretus was used to construct a multilocus map of Chromosome 17 consisting of 12 new anonymous loci and 9 anchor loci. In addition, 7 anonymous DNA loci were added to the Chr 17 map for the BXD strains. Although we were able to identify readily the most likely gene order in the interspecific backcross, we found no evidence for an unambiguous gene order using the BXD recombinant inbred strains. Comparison of the interspecific backcross map and the BXD RI strain map revealed evidence in the interspecific backcross for a longer total genetic length, enhanced recombination distal to H-2, a segment showing suppressed recombination, and strong interference.
Recommended Citation
Nadeau JH,
Herrmann B,
Bucan M,
Burkart D,
Crosby JL,
Erhart MA,
Kosowsky M,
Kraus JP,
Michiels F,
Schnattinger A,
Varnum D.
Genetic maps of mouse chromosome 17 including 12 new anonymous DNA loci and 25 anchor loci. Genomics 1991 Jan;9(1):78-89