Faculty Research 1990 - 1999

Title

Genetic maps of mouse chromosome 17 including 12 new anonymous DNA loci and 25 anchor loci.

Document Type

Article

Publication Date

1991

Keywords

Chromosome-Mapping, Crosses-Genetic, DNA: ge, Genetic-Markers, Mice, Mice-Inbred-C57BL, Muridae, Recombination-Genetic, Restriction-Fragment-Length-Polymorphisms, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genomics 1991 Jan;9(1):78-89

Grant

HG00189, GM39821, GM11800

Abstract

An interspecific backcross between lab mice and Mus spretus was used to construct a multilocus map of Chromosome 17 consisting of 12 new anonymous loci and 9 anchor loci. In addition, 7 anonymous DNA loci were added to the Chr 17 map for the BXD strains. Although we were able to identify readily the most likely gene order in the interspecific backcross, we found no evidence for an unambiguous gene order using the BXD recombinant inbred strains. Comparison of the interspecific backcross map and the BXD RI strain map revealed evidence in the interspecific backcross for a longer total genetic length, enhanced recombination distal to H-2, a segment showing suppressed recombination, and strong interference.