Faculty Research 1990 - 1999

Title

The mouse polycystic kidney disease mutation (cpk) is located on proximal chromosome 12.

Document Type

Article

Publication Date

1991

Keywords

Chromosome-Mapping, Crosses-Genetic, Female, Kidney-Polycystic: ge, Linkage-(Genetics), Male, Mice, Mice-Inbred-C57BL, Mice-Inbred-DBA, Mutation, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Translocation-(Genetics)

JAX Source

Genomics 1991 Apr;9(4):778-81

Grant

RR01183, GM32105

Abstract

The mouse congenital polycystic kidney (cpk) mutation produces a condition that resembles human autosomal recessive polycystic kidney disease (ARPKD) in its pattern of inheritance, clinical progression, and histopathology. Inheritance of this mouse mutation in crosses segregating the Rb(12.14)8Rma translocation chromosome and various DNA markers of Chromosome 12 have localized cpk to a site near D12Nyu2, approximately 7 cM from the centromere of Chromosome 12. This result suggests that the homologous PKD2 gene should be localized to either human chromosome 2p23-p25 or chromosome 7q22-q31.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS