Faculty Research 1990 - 1999

Title

The mouse Y* chromosome involves a complex rearrangement, including interstitial positioning of the pseudoautosomal region.

Document Type

Article

Publication Date

1991

Keywords

Base-Sequence, Blotting-Southern, Centromere, Female, Fertility: ge, Fluorescence, Heterochromatin, Karyotyping, Male, Mice, Mice-Inbred-Strains, Mitosis: ge, Molecular-Sequence-Data, Nucleic-Acid-Hybridization, Recombination-Genetic: ge, Sex-Chromosome-Abnormalities: ge, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, X-Chromosome, Y-Chromosome

JAX Source

Cytogenet Cell Genet 1991;57(4):221-30

Grant

GM20919

Abstract

Cytological analysis of the mouse Y* chromosome revealed a complex rearrangement involving acquisition of a functional centromere and centromeric heterochromatin and attachment of this chromosomal segment to the distal end of a normal Y* chromosome. This rearrangement positioned the Y* short-arm region at the distal end of the Y* chromosome and the pseudoautosomal region interstitially, just distal to the newly acquired centromere. In addition, the majority of the pseudoautosomal region was inverted. Recombination between the X and the Y* chromosomes generates two new sex chromosomes: (1) a large chromosome comprised of the X chromosome attached at its distal end to all of the Y* chromosome but missing the centromeric region (XY*) and (2) a small chromosome containing the centromeric portion of the Y* chromosome attached to G-band-negative material from the X chromosome (YX). Mice that inherit the XY* chromosome develop as sterile males, whereas mice that inherit the Y*X chromosome develop as fertile females. Recovery of equal numbers of recombinant and nonrecombinant offspring from XY* males supports the hypothesis that recombination between the mammalian X and Y chromosomes is necessary for primary spermatocytes to successfully complete spermatogenesis and form functional sperm.

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