Faculty Research 1990 - 1999

Title

C-band polymorphisms in exotic inbred strains of mice: a method for mapping centromeric ends of chromosomes.

Document Type

Article

Publication Date

1991

Keywords

Centromere, Chromosome-Banding, Chromosome-Mapping: mt, DNA-Satellite: ge, Genetic-Markers, Heterochromatin, Male, Mice, Mice-Inbred-Strains: ge, Polymorphism-(Genetics), SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Cytogenet Cell Genet 1991;57(4):217-20

Grant

RR01183

Abstract

The major satellite DNA of Mus musculus appears as a pericentromeric heterochromatin block in all chromosomes but the Y. While C-banding readily reveals the presence of this heterochromatin block, there is considerable polymorphism in C-band size among the chromosomes and among different subspecies. We have studied the distribution of C-band size differences in the chromosomes of 15 exotic inbred laboratory strains and substrains derived from wild populations of different subspecies of M. musculus. The variation in C-band size among these inbred strains can serve as a useful codominant cytological marker for estimating recombinational distances between the centromere and proximal genes in linkage crosses.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS