Faculty Research 1990 - 1999

Title

Intercommunication between mammalian oocytes and companion somatic cells.

Document Type

Article

Publication Date

1991

Keywords

Cell-Communication, Female, Graafian-Follicle: cy, ph, Homeostasis, Mammals, Meiosis, Models-Biological, Oocytes: cy, ph, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Bioessays 1991 Nov;13(11):569-74

Grant

HD20575, HD23839, HD21970

Abstract

Cellular interactions in the mammalian ovarian follicle between its germ-line and somatic cell components are crucial for its development and function. These interactions are mediated by both membrane gap junctions and paracrine factors. Somatic cell-to-oocyte communication is essential for oocyte growth and the regulation of meiotic maturation. In particular, granulosa cells provide nutrients and molecular signals that regulate oocyte development. Oocytes, on the other hand, promote the organization of the follicle, the proliferation of granulosa cells, and the differentiation and function of cumulus cells, a subset of granulosa cells. Determining the nature of the oocyte-to-granulosa cell signals remains a key challenge for future work.

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