Faculty Research 1990 - 1999

Title

Mapping anti-m:ullerian hormone (Amh) and related sequences in the mouse: identification of a new region of homology between MMU10 and HSA19p.

Document Type

Article

Publication Date

1991

Keywords

Chromosome-Mapping, Chromosomes-Human-Pair-19, Crosses-Genetic, Female, Genes-Structural, Genetic-Markers, Growth-Inhibitors: ge, Human, Male, Mice: ge, Mice-Inbred-Strains, Morphogenesis: ge, Mullerian-Ducts: em, Muridae: ge, Restriction-Fragment-Length-Polymorphisms, Sequence-Homology-Nucleic-Acid, SUPPORT-U-S-GOVT-P-H-S, Testicular-Hormones: ge, Transforming-Growth-Factor-beta: ge

JAX Source

Genomics 1991 Oct;11(2):273-83

Grant

GM20919, CA09217

Abstract

A panel of 78 backcross progeny, BALB/cJ x (BALB/cJ x CAST/Ei)F1, was used to map the gene encoding anti-M:ullerian hormone (Amh), also called M:ullerian inhibiting substance, to mouse Chromosome 10 (MMU10). This analysis identified a new region of linkage homology between human Chromosome 19p (HSA 19p) and MMU10 and localized an apparent recombinational hot spot in (C57BL/6J x Mus spretus)F1 females [compared with (BALB/cJ x CAST/Ei)F1 males] to the interval between phenylalanine hydroxylase (Pah) and mast cell growth factor (Mgf). In addition, eight unlinked polymorphic sequences, provisionally designated Amh-related sequences (Amh-rs1 through Amh-rs8), were identified by Southern blot analysis using Amh probes. Amh-rs1, -rs2, -rs4, and -rs7 were mapped to MMU1, 13, 12, and 15, respectively, by recombinant inbred (RI) strain and intraspecific backcross analyses. The NXSM RI strain distribution patterns for the four unmapped loci are also presented.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS