Faculty Research 1990 - 1999
Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells.
Document Type
Article
Publication Date
1991
Keywords
Animal, Base-Sequence, Blotting-Northern, Cadherins: ge, me, Cell-Differentiation, Cell-Line, Cloning-Molecular, DNA: ge, Fluorescent-Antibody-Technique, Gene-Expression, Mice, Molecular-Sequence-Data, Muscle-Proteins: ge, me, Muscles: cy, ph, RNA-Messenger: ge, SUPPORT-NON-U-S-GOVT
First Page
8024
Last Page
8028
JAX Source
Proc Natl Acad Sci U S A 1991 Sep 15;88(18):8024-8
Abstract
Cadherins, a multigene family of transmembrane glycoproteins, mediate Ca(2+)-dependent intercellular adhesion. They are thought to be essential for the control of morphogenetic processes, including myogenesis. Here we report the identification and characterization of the cDNA of another member of the cadherin family, M-cadherin (M for muscle), from differentiating muscle cells. The longest open reading frame of the cDNAs isolated contains almost the entire coding region of the mature M-cadherin as determined by sequence homology to the known cadherins. M-cadherin mRNA is present at low levels in myoblasts and is upregulated in myotube-forming cells. In mouse L cells (fibroblasts), M-cadherin mRNA is undetectable. This expression pattern indicates that M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
Recommended Citation
Donalies M,
Cramer M,
Ringwald M,
Starzinski PA.
Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. Proc Natl Acad Sci U S A 1991 Sep 15;88(18):8024-8