Faculty Research 1990 - 1999

Title

Defective repair of radiation-induced chromosomal damage in scid/scid mice.

Document Type

Article

Publication Date

1992

Keywords

Cells-Cultured, Chromosome-Aberrations, Chromosomes: re, Dose-Response-Relationship-Radiation, DNA-Repair, Gamma-Rays, Mice, Mice-SCID: ge, Mutation: ge, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Cytogenet Cell Genet 1992;59(1):39-44

Grant

CA20408, AI30389, DK07449

Abstract

The murine severe combined immunodeficiency (scid) mutation interferes with normal recombination of immunoglobulin and T-cell receptor genes. This immunologic defect results in a lack of fully differentiated B and T cells in scid/scid mice. Animals homozygous for the scid mutation also display increased sensitivity to the damaging effects of ionizing radiation. We report here our observations of high frequencies of radiation-induced chromatid interchanges and intrachanges in bone marrow cells and fibroblasts from scid/scid mice. The presence of these aberrant chromosome structures suggests that a delay in strand rejoining underlies the increased sensitivity of scid/scid mice to ionizing radiation. The scid mutation may provide important clues for understanding the relationship between mitotic recombination and DNA repair in higher eukaryotic cells.

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