Faculty Research 1990 - 1999

Title

Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/B1NJ and SM/J inbred strains.

Document Type

Article

Publication Date

1992

Keywords

Blotting-Southern, Crosses-Genetic, Female, Linkage-(Genetics), Male, Mice, Mice-Inbred-NZB, Mice-Inbred-Strains, Mouse-Leukemia-Viruses: ge, Proviruses: ge, Restriction-Mapping, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Virus-Integration: ge

JAX Source

Mamm Genome 1992;2(2):110-22

Grant

GM20919, RR01183

Abstract

We characterized 84 endogenous nonecotropic proviruses of NZB/B1NJ and SM/J inbred strains by examining proviral junction fragment segregation in recombinant inbred (RI) and backcross mice. Forty-five proviruses were shared with other laboratory strains, but 28 were unique to NZB/B1NJ or SM/J. Proviral loci were located on 17 of the 19 mouse autosomes and on both sex chromosomes. These markers will facilitate gene mapping in the NXSM RI set and contribute to the pursuit of a more complete map of the mouse genome.

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