Faculty Research 1990 - 1999

Title

Microcephalic cerebrum with hypomyelination in the congenital goiter mouse (cog).

Document Type

Article

Publication Date

1992

Keywords

Brain: ab, Cell-Division: ph, Disease-Models-Animal, Goiter: cn, pp, pa, Mice, Mice-Mutant-Strains, Microcephaly: et, pa, Motor-Activity: ph, Myelin-Sheath: ph, Neuroglia: cy, SUPPORT-NON-U-S-GOVT

JAX Source

Neurochem Res 1992 Oct;17(10):1037-40

Abstract

2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in the cerebrum of the congenital goiter mouse (cog/cog) is reduced in comparison with the normal heterozygote (cog/+). The weight of the cog/cog cerebrum and cerebellum were significantly less than those of the normal controls, 89.0% less for the cerebrum, and 81.1% less for the cerebellum. However, no differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the congenital goiter mouse is restricted to the cerebrum, and is not related to arrested glial proliferation.

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