Faculty Research 1990 - 1999

Title

Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.

Document Type

Article

Publication Date

1992

Keywords

Animal, Blotting-Southern, Chromosome-Deletion, Crosses-Genetic, DNA: ge, Eye-Color: ge, Female, Genes-Recessive, Genotype, Male, Mice, Mice-Inbred-Strains, Mice-Mutant-Strains, Mutation, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Proc Natl Acad Sci U S A 1992 Aug 1;89(15):6968-72

Grant

GM20919, CA09217, GM43840

Abstract

Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.

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