Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.
Animal, Blotting-Southern, Chromosome-Deletion, Crosses-Genetic, DNA: ge, Eye-Color: ge, Female, Genes-Recessive, Genotype, Male, Mice, Mice-Inbred-Strains, Mice-Mutant-Strains, Mutation, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
Proc Natl Acad Sci U S A 1992 Aug 1;89(15):6968-72
GM20919, CA09217, GM43840
Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.
Lyon, M F.; King, T R.; Gondo, Y; Gardner, J M.; Nakatsu, Y; Eicher, E M.; and Brilliant, M H., " Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse." (1992). Faculty Research 1990 - 1999. 247.
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