Faculty Research 1990 - 1999

Title

Genetic linkage analysis of the murine developmental mutant velvet coat (Ve) and the distal chromosome 15 developmental genes Hox-3.1, Rar-g, Wnt-1, and Krt-2.

Document Type

Article

Publication Date

1992

Keywords

Carrier-Proteins: ge, Chromosome-Mapping, Crosses-Genetic, DNA-Binding-Proteins: ge, Female, Genes-Homeo-Box, Genes-Structural, Hair, Keratin: ge, Linkage-(Genetics), Male, Mice, Mice-Inbred-BALB-C, Mutation, Proto-Oncogene-Proteins: ge, Restriction-Fragment-Length-Polymorphisms, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J Exp Zool 1992 Aug 1;263(1):83-95

Grant

GM009966, GM006543

Abstract

We have identified restriction fragment length polymorphisms between Mus musculus and Mus spretus for the Chromosome 15 loci Hox-3, Wnt-1, Krt-2, Rar-g, and Ly-6. We followed the inheritance of these alleles in interspecific genetic test crosses between velvet coat (Ve) heterozygotes and M. spretus. The results suggest a gene order and recombination distances (in cM) of Ly-6-22-Wnt-1-2-Ve/Krt-2/Rar-g-3-Hox-3. No recombination was found between Ve, Krt-2, and Rar-g. The data also provide evidence for the hypothesis of a large-scale genomic duplication involving homologous gene pairs on mouse Chromosomes 15 and 11.

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