Faculty Research 1990 - 1999

Title

Confirmation of the influence of a chromosome 7 locus on susceptibility to audiogenic seizures.

Document Type

Article

Publication Date

1992

Keywords

Alleles, Animal, Chromosome-Mapping, Chromosomes, Crosses-Genetic, Disease-Susceptibility: ge, Female, Male, Mice, Mice-Inbred-A, Mice-Inbred-DBA, Seizures: ge, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Mamm Genome 1992;3(5):250-3

Grant

GM23618, P30-HD-18655

Abstract

Mouse strain differences in susceptibility to audiogenic seizures (AGS) are due to allelic differences at multiple genetic loci. Three loci that influence susceptibility to AGS have been mapped on Chromosomes (Chr) 12, 4, and 7 (Asp-1, Asp-2, and Asp-3, respectively). Here we report evidence that confirms linkage of Asp-3 to c on Chr 7 and parental effects on AGS susceptibility, but not genomic imprinting of Asp-3.

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