Faculty Research 1990 - 1999

Title

Forestomach papillomas in flaky skin and steel-Dickie mutant mice.

Document Type

Article

Publication Date

1992

Keywords

Animal, Antigens-Viral: an, Blotting-Southern, Comparative-Study, DNA-Probes-HPV, DNA-Viral: an, Homozygote, Immunohistochemistry, Male, Mice, Mice-Mutant-Strains, Papilloma: ge, mi, pa, ve, Papillomaviruses: ge, im, Phenotype, Rodent-Diseases: ge, mi, pa, Stomach: pa, Stomach-Neoplasms: ge, mi, pa, ve, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J Vet Diagn Invest 1992 Jul;4(3):312-7

Grant

CA34196, AR40324

Abstract

Gastric papillomas were diagnosed in flaky skin (fsn/fsn) and steel-Dickie (Sl/Sld) mutant mice but not littermate controls. Both mutants suffer from severe anemia of differing causes. Immunohistochemical screening and Southern blot analyses failed to detect any evidence of a papillomavirus in the gastric lesions. Phenotypic expression of the fsn and Sld mutant genes may play an essential role in the spontaneous development of forestomach papillomas in these mouse mutants.

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