Faculty Research 1990 - 1999

Title

Genetic mapping of a new homeobox gene to mouse chromosome 7.

Document Type

Article

Publication Date

1992

Keywords

Autoradiography, Blotting-Southern, Brain: em, me, Chromosome-Mapping, Crosses-Genetic, DNA, DNA-Probes, Genes-Homeo-Box, Linkage-(Genetics), Mice, Spinal-Cord: em, me, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genomics 1992 Dec;14(4):1107-9

Grant

RR01183/RR/NCRR, GM09966/GM/NIGMS

Abstract

A newly identified homeobox gene designated Dbx has been mapped to mouse Chromosome (Chr) 7. This gene is expressed in a restricted manner in developing mouse brain and spinal cord and has amino acid sequence similarities with members of the homeobox gene family such as Drosophila H2.0 and mouse Hlx. Using a fragment of the Dbx cDNA as a probe, a PstI restriction fragment length polymorphism was used to determine genotypes of 144 progeny from an interspecific backcross. Segregation analysis revealed linkage of Dbx with six prepositioned reference loci on mouse Chr 7. No recombination was observed between Dbx and Odc-rs6, indicating that Dbx lies approximately 25 cM distal to the Chr 7 centromere in a region that has conserved linkage relationships with regions of human Chrs 11 and 19.

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