Faculty Research 1990 - 1999

Title

Functional epidermal growth factor receptor localizes to the postacrosomal region of human spermatozoa.

Document Type

Article

Publication Date

1993

Keywords

Cell-Compartmentation, Fluorescent-Antibody-Technique, Human, Male, Phosphorylation, Protein-Tyrosine-Kinase: me, Receptors-Epidermal-Growth-Factor-Urogastrone: me, Spermatozoa: me, ul, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Biochem Biophys Res Commun 1993 Feb 15;190(3):901-6

Grant

HD21355/HD/NICHD, CA10815/CA/NCI

Abstract

The human epidermal growth factor receptor was detected immunohistochemically in the postacrosomal region of ejaculated human sperm and, when immunopurified and exposed to [gamma-32P]ATP, was found to be autophosphorylated. Localization of an apparently enzymatically active epidermal growth factor receptor to spermatozoa suggests that epidermal growth factor receptor-ligand interactions may play a role in gamete physiology or in fertilization.

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