Faculty Research 1990 - 1999

Title

Identification and genetic mapping of the murine gene and 20 related sequences encoding chromosomal protein HMG-17.

Document Type

Article

Publication Date

1993

Keywords

Base-Sequence, Chromosome-Mapping, Crosses-Genetic, DNA, Female, High-Mobility-Group-Proteins: ge, Human, Male, Mice, Mice-Inbred-C57BL, Mice-Inbred-Strains, Molecular-Sequence-Data, Restriction-Fragment-Length-Polymorphisms, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Mamm Genome 1993;4(2):83-9

Grant

RR01183/RR/NCRR, CA34196/CA/NCI, GM46697/GM/NIGMS

Abstract

HMG-17 is an abundant, nonhistone chromosomal protein that binds preferentially to nucleosomal core particles of mammalian chromatin. The human gene for HMG-17 has been localized to Chromosome (Chr) 1p, but the murine gene has not been previously mapped. Here we identify the murine functional gene, Hmg17, from among more than 25 related sequences (probably processed pseudogenes) and show that it is located on mouse Chr 4, in a region known to have conserved linkage relationships with human Chr 1p. We also report the map locations of 20 additional Hmg17-related sequences on mouse Chrs 1, 2, 3, 5, 7, 8, 9, 13, 15, 16, 17, 18, and X. The multiple, dispersed members of the Hmg17 multigene family can be detected efficiently with a single cDNA probe and provide useful markers for genetic mapping studies in mice.

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