Faculty Research 1990 - 1999

Title

Newly acquired peri-telomeric heterochromatin in a transgenic mouse lineage.

Document Type

Article

Publication Date

1993

Keywords

Cell-Line, Chromosome-Banding, Chromosomes: ul, Female, Heterochromatin: ul, Karyotyping, Male, Mice, Mice-Inbred-C57BL, Mice-Transgenic, Pedigree, Stem-Cells: ul, SUPPORT-U-S-GOVT-P-H-S, Telomere: ul

JAX Source

Cytogenet Cell Genet 1993;62(4):211-3

Grant

HD21355/HD/NICHD, CA18470/CA/NCI, CA37227/CA/NCI

Abstract

Karyotypes of an embryonic stem cell line and normal bone marrow and peripheral blood cells from a transgenic mouse lineage, strain 83, exhibit a novel region of constitutive heterochromatin in the peri-telomeric region of chromosome 3. This heterochromatic region co-localizes with the integration site of the transgene, an 11-Mb tandem insertion of a plasmid containing human beta-globin gene sequences, and is inherited in Mendelian fashion. The significance of this finding is discussed, and a nomenclature for such newly acquired heterochromatic regions is suggested.

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