Faculty Research 1990 - 1999

Title

Immune function in lines of mice selected for high or low degrees of behavioral asymmetry.

Document Type

Article

Publication Date

1990

Keywords

Behavior-Animal: ph, Comparative-Study, Immune-System: ph, Killer-Cells-Natural: im, Laterality: ph, Leukocyte-Culture-Test-Mixed, Male, Mice, Psychoneuroimmunology, Species-Specificity, Support-U, S, -Gov't-Non-P, H, S, Support-U, S, -Gov't-P, H, S, T-Lymphocytes-Cytotoxic: im

JAX Source

Brain Behav Immun 1990 Jun; 4(2):129-38.

Grant

GM23618

Abstract

Cerebral lateralization has been suggested to play a regulatory role in immune function. In this study, several measures of immune function were evaluated in mice selectively bred for either a strong (HI) or weak (LO) degree of behavioral asymmetry (paw preference) and compared to an unselected control population (HET). Both HI and LO animals had fewer spleen cells but higher degrees of [3H]thymidine incorporation into DNA (on a per cell basis) than HET mice. However, only HI mice had lower immune functions compared to HET controls manifest as reduced mixed leukocyte reaction (MLR), cytotoxic T lymphocyte (CTL) activity, and natural killer (NK) cell activity. These findings indicate that although both extremes in the degree of paw preference may be associated with deviations from the norm, a high degree of behavioral lateralization is associated with decreased immune responsiveness in this animal model.

Please contact the Joan Staats Library for information regarding this document.

Share

COinS