Faculty Research 1990 - 1999

Title

The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci.

Document Type

Article

Publication Date

1990

Keywords

Blotting-Southern, Chromosome-Mapping, Crosses-Genetic, DNA-Probes, Female, Genes, Linkage-(Genetics), Male, Mammary-Cancer-Virus, Mice, Mice-Inbred-Strains, Mink-Cell-Focus-Inducing-Viruses, Proviruses, Recombination-Genetic, Repetitive-Sequences-Nucleic-Acid, Support-U, S, -Gov't-P, H, S

JAX Location

1,949.

JAX Source

Genetics 1990 Jun; 125(2):431-46.

Grant

RR01183, GM20919

Abstract

We report the construction of 17 recombinant inbred (RI) strains of mice derived from the progenitor strains NZB/BINRe and SM/J and the typing of this RI strain set, designated NXSM, for 58 loci distributed on 16 autosomes and the X chromosome. Two backcrosses involving NZB/BINJ and SM/J were constructed to confirm chromosomal assignments and determine gene orders suggested from NXSM RI strain data. From these results we recommend that chromosomal assignments and gene orders suggested from analyses of RI strain sets be confirmed using data obtained by other means. We also typed NZB/BINJ and SM/J for mammary tumor proviral (Mtv) loci. Both strains share three previously described Mtv loci: Mtv-7, Mtv-14 and Mtv-17. In addition, NZB/BINJ contains the previously described Mtv-3 and Mtv-9 loci and two new Mtv proviral loci: Mtv-27 located on chromosome (Chr) 1 and Mtv-28 located on the X chromosome. SM/J contains the previously described loci Mtv-6 and Mtv-8. Four LTR, mink cell focus-forming murine leukemia viral loci were identified and mapped: Ltrm-1 on Chr 12, Ltrm-2 on Chr 16, Ltrm-3 on Chr 5, and Ltrm-4 on Chr 13. The Tgn locus was positioned proximal to the Ly-6 locus on Chr 15.

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