Faculty Research 1990 - 1999

Title

Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice.

Document Type

Article

Publication Date

1994

Keywords

B-Lymphocytes: im, cy, Cell-Division: ge, Estrogen-Replacement-Therapy, Estrogens: df, ph, tu, Female, Gonadorelin: ge, Hypogonadism: dt, ge, im, Interleukin-7: ph, Mice, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J Exp Med 1994 Aug 1;180(2):717-20

Grant

AI20069/AI/NIAID, AI30389/AI/NIAID, CA20408/CA/NCI

Abstract

Interleukin 7 (IL-7) responsive B lineage precursors were greatly expanded in genetically hypogonadal female (HPG/Bm-hpg/hpg) mice that have a secondary deficiency in gonadal steroidogenesis. Estrogen replacement in these mice resulted in a dose-dependent reduction in B cell precursors. More modest increases were documented in genetically normal mice that were surgically castrated. These findings complement other recent observations that B lymphopoiesis selectively declines in pregnant or estrogen-treated animals. Sex steroids have long been known to influence such disparate processes as bone physiology and tumor growth, in addition to their importance for reproductive function. We now show that these hormones are important negative regulators of B lymphopoiesis.