Faculty Research 1990 - 1999

Title

The mouse as a model for human cardiovascular disease and hyperlipidemia.

Document Type

Article

Publication Date

1994

Keywords

Atherosclerosis: ge, Cardiovascular-Diseases: ge, Disease-Models-Animal, Human, Hyperlipidemia: ge, Mice

JAX Source

Curr Opin Lipidol 1994 Aug;5(4):258-64

Abstract

The mouse has been used as an experimental model for atherosclerosis research for only a short time; however, the sophisticated genetics of this species has resulted in a number of innovative approaches that are not possible with other models. The availability of inbred, congenic, recombinant inbred, and mutant strains has resulted in the discovery of a number of genes affecting atherosclerosis susceptibility. More importantly, the newer genetic technologies such as quantitative trait-loci mapping, transgenic mice, and gene-targeted mice are producing important insights into atherosclerosis. This review, focusing on murine models of cardiovascular disease and hyperlipidemia, will be divided into two parts: naturally occurring models and genetically engineered models.

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