Faculty Research 1990 - 1999

Title

Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse.

Document Type

Article

Publication Date

1994

Keywords

Chromosome-Mapping, Comparative-Study, Crosses-Genetic, Female, Genes-Reiterated, Haplotypes: ge, Male, Mice: ge, Mice-Inbred-C57BL, Mice-Inbred-Strains, Muridae: ge, Polymorphism-Restriction-Fragment-Length, Recombination-Genetic, Ribosomal-Proteins: ge, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Mamm Genome 1994 Nov;5(11):670-87

Grant

GM46697/GM/NIGMS, RR01183/RR/NCRR, CA34196/CA/NCI

Abstract

More than 150 individual members of 16 ribosomal protein multigene families were identified as DNA restriction fragments and genetically mapped. The ribosomal protein gene-related sequences are widely dispersed throughout the mouse genome. Map positions were determined by analysis of 144 progeny mice from both an interspecific (C57BL/6J x SPRET/Ei)F1 x SPRET/Ei and an intersubspecific (C57BL/6J x CAST/Ei)F1 x C57BL/6J backcross. In addition, 30 members of the multigene families encoding PGK1 ODC, and TPI, including five new loci for ODC and one new locus for TPI, were characterized and mapped. Interspecific backcross linkage data for 29 nonecotropic murine leukemia retroviruses endogenous to C57BL/6J mice are also reported. Transmission ratio distortions and recombination frequencies are compared between the two backcrosses.

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