Faculty Research 1990 - 1999

Title

Genetic and pathogenic basis of autoimmune diabetes in NOD mice.

Document Type

Article

Publication Date

1994

Keywords

Autoantigens: im, Autoimmunity: im, Diabetes-Mellitus-Insulin-Dependent: ge, im, Haplotypes, Human, Islets-of-Langerhans: im, Major-Histocompatibility-Complex: ge, im, Mice, Mice-Inbred-NOD, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes: im

JAX Source

Curr Opin Immunol 1994 Dec;6(6):900-6

Grant

DK46266/DK/NIDDK, DK27722/DK/NIDDK, DK36175/DK/NIDDK

Abstract

Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this disease is a result of epistatic interactions between multiple genes, both inside and outside the major histocompatibility complex (MHC), generating T cells reactive against an expanding repertoire of autoantigens.

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