Faculty Research 1990 - 1999

Title

A quantitative study of cerebrovascular variation in inbred mice.

Document Type

Article

Publication Date

1990

Keywords

Circle-of-Willis: ah, hi, Comparative-Study, Dyes: du, Mice, Mice-Inbred-BALB-C: ah, ge, hi, Mice-Inbred-C57BL: ah, ge, hi, Mice-Inbred-Strains: ah, ge, hi, Phenotype, Polymorphism-(Genetics), SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J Anat 1990 Dec; 173:87-95.

Grant

GM23618

Abstract

The arteries of the base of the mouse brain were examined after perfusion with India ink. A qualitative difference exists between inbred mice of three strains (C57BL/6J, 129/J and BALB/cCF) on the one hand, and genetically defined heterogeneous mice on the other; the latter consistently show anomalies similar to those previously described in genetically undefined rodents, whereas inbred mice do not. A quantitative morphometric analysis of the Circle of Willis of inbred mice was undertaken. The results of this analysis are consistet with the notion that the differences in shape between the circles of Willis of different strains of inbred mice are due to additive genetic variation between these strains.

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