Faculty Research 1990 - 1999

Title

Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19 that causes motor neuron degeneration.

Document Type

Article

Publication Date

1995

Keywords

Chromosome-Mapping: mt, Crosses-Genetic, Female, Glycogen-Phosphorylase: ge, Male, Mice, Mice-Inbred-CBA, Mice-Inbred-C57BL, Motor-Neurons: ph, pa, Muscle-Skeletal: pa, Muscular-Atrophy-Spinal: ge, pa, Mutation: ge, Nerve-Degeneration: ge, Nerve-Growth-Factors: ge, Nerve-Tissue-Proteins: ge, Spinal-Cord: pa, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Mamm Genome 1995 Mar;6(3):187-91

Grant

RR01183/RR/NCRR, GM46697/GM/NIGMS, CA34196/CA/NCI

Abstract

Neuromuscular degeneration, nmd, is a spontaneous autosomal recessive mutation in the mouse producing progressive hindlimb impairment caused by spinal muscular atrophy. We used an intersubspecific intercross between B6.BKs-nmd2J/+ and Mus musculus castaneus (CAST/Ei) to map the nmd mutation to mouse Chromosome (Chr) 19 with the most likely gene order: nmd-(D19Sel2, Pygm)-Cntf-Pomc2-D19Mit16-Cyp2c-Got1. nmd maps near muscle deficient, mdf, and has a very similar clinical phenotype, but allele tests and histological differences suggest that nmd is a distinct mutation at a different locus. Although closely linked, nmd recombined with the candidate genes muscle glycogen phosphorylase, Pygm, and ciliary neurotrophic factor, Cntf.

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