Faculty Research 1990 - 1999

Title

Localization of the growth hormone gene to the distal half of mouse chromosome 11.

Document Type

Article

Publication Date

1990

Keywords

Animal, Chromosome-Mapping, Comparative-Study, Crosses-Genetic, Female, Genetic-Markers, Human, Male, Mice: ge, Mice-Inbred-Strains: ge, Recombination-Genetic, Somatotropin: ge, Species-Specificity, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genomics 1990 Nov; 8(3):591-4.

Grant

GM28464, GM20919, RR01183

Abstract

A DNA fragment size variant for the growth hormone gene, Gh, has been identified among inbred strains of mice. The inbred strains SM/J and CAST/Ei carry the less frequent allele Ghb and 11 other strains carry the Gha allele. Segregation analysis of data from two crosses involving SM/J and NZB/BINJ and a cross involving BALB/cJ and CAST/Ei confirmed the assignment of Gh to mouse chromosome 11 and placed the locus 2.6 +/- 1.8 map units distal to Erba (avian erythroblastosis oncogene A), a position consistent with the assignment of the Gh locus to the q22-q24 region of chromosome 17 on the human map. Segregation analysis also refined the location of Sparc (secreted acidic cysteine-rich glycoprotein) on mouse chromosome 11 to a position 16.7 +/- 4.2 map units proximal to Evi-2 (ecotropic viral integration site 2).

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