Faculty Research 1990 - 1999

Title

Localization of the gene for the trans-acting transcription factor Sp1 to the distal end of mouse chromosome 15.

Document Type

Article

Publication Date

1990

Keywords

Chromosome-Mapping, Comparative-Study, Crosses-Genetic, DNA: ge, Female, Genes-Structural, Genetic-Markers, Human, Linkage-(Genetics), Male, Mice: ge, Mice-Inbred-Strains: ge, Muridae: ge, Recombination-Genetic, Restriction-Fragment-Length-Polymorphisms, Species-Specificity, SUPPORT-NON-U-S-GOVT, Transcription-Factor-Sp1: ge, Zinc-Fingers

JAX Source

Genomics 1990 Nov; 8(3):571-4.

Abstract

The mouse chromosomal location for the gene (Sp1-1) encoding the trans-acting transcription factor Sp1 has been determined. Analysis of restriction fragment length polymorphisms in recombinant inbred, congenic, and interspecific backcross mice using human and mouse cDNA probes demonstrated that Sp1-1 is a single gene closely linked to the mammary tumor virus integration site-1 (Int-1) on the distal end of chromosome 15. Sp1 is a zinc finger protein, but Sp1-1 is not closely linked to any of the other zinc finger protein genes that have been mapped in mouse. Int-1 and other markers flanking the Sp1-1 locus are part of a conserved linkage group represented on human chromosome 12q.

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