Faculty Research 1990 - 1999
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation.
Document Type
Article
Publication Date
1995
First Page
70
Last Page
74
JAX Source
Nature 1995 Jul 6;376(6535):70-4
Abstract
Tie-1 and Tie-2 define a new class of receptor tyrosine kinases that are specifically expressed in developing vascular endothelial cells. To study the functions of Tie-1 and Tie-2 during vascular endothelial cell growth and differentiation in vivo, targeted mutations of the genes in mice were introduced by homologous recombination. Embryos deficient in Tie-1 failed to establish structural integrity of vascular endothelial cells, resulting in oedema and subsequently localized haemorrhage. However, analyses of embryos deficient in Tie-2 showed that it is important in angiogenesis, particularly for vascular network formation in endothelial cells. This result contrasts with previous reports on Tie-2 function in vasculogenesis and/or endothelial cell survival. Our in vivo analyses indicate that the structurally related receptor tyrosine kinases Tie-1 and Tie-2 have important but distinct roles in the formation of blood vessels.
Recommended Citation
Sato TN,
Tozawa Y,
Deutsch U,
Wolburg BK,
Fujiwara Y,
Gendron MM,
Gridley T,
Wolburg H,
Risau W,
Qin Y.
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 1995 Jul 6;376(6535):70-4