Faculty Research 1990 - 1999

Title

Patchy fur (Paf), a semidominant X-linked gene associated with a high level of X-Y nondisjunction in male mice.

Document Type

Article

Publication Date

1990

Keywords

Chromosome-Aberrations, Crosses-Genetic, Female, Hair-Color: ge, Karyotyping, Linkage-(Genetics), Male, Meiosis, Mice, Mutation, Nondisjunction-Genetic, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, X-Chromosome, Y-Chromosome

JAX Location

1,921.

JAX Source

J Hered 1990 Jan-Feb; 81(1):43-50.

Grant

CA34196

Abstract

Several X-linked mutations that have associated sex chromosomal nondisjunction have been identified in the mouse. We describe a new semidominant X-linked mutation called patchy fur (Paf) that produces an abnormal coat. It maps to the distal end of the murine X chromosome very near the XY pseudoautosomal region. The degree of severity in affected mice is hemizygous males greater than homozygous females greater than heterozygous females. An unusual feature of Paf is that either the mutation itself or an inseparable chromosomal abnormality causes delayed disjunction of the X and Y chromosomes at meiotic metaphase I, which in turn results in approximately 19% XO progeny and slightly less than 1% XXY progeny from Paf/Y males. The effect occurs only in male carriers and thus must extend into the proximal end of the XY pairing region.

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