Faculty Research 1990 - 1999

Title

L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males.

Document Type

Article

Publication Date

1996

Keywords

Animal, Eating: de, Female, Fertility: de, Male, Mice, Selegiline, Superoxide-Dismutase: me, SUPPORT-U-S-GOVT-P-H-S

JAX Source

J Gerontol A Biol Sci Med Sci 1996 Nov;51(6):B448-53

Grant

AG10838/AG/NIA, AG11643/AG/NIA

Abstract

Male and female B6D2F1 (C57BL/6J x DBA/2J)F1 and B6CBAF1 (C57BL/6J x CBA/CaHT6J)F1 mice were injected subcutaneously 3 times a week with L-deprenyl (0.25 mg/kg) starting at mean ages of 26 months and 18.5 months, respectively. Life spans of aging mice were increased 6-9% by the drug. While none of the life span effects were significant for a single genotype and gender, life spans were significantly longer in L-deprenyl-treated animals (p = .011) when all data were combined. L-deprenyl-injected mice consumed about the same amounts of food as controls: L-deprenyl 3.1 g/day, control 3.3 g/day, after 7 months of treatment. There were no significant effects of L-deprenyl on measures of changes with age in the following biological systems: activity, excitement, red blood cell mass, collagen denaturation rate, and wound healing rate. L-deprenyl-treated B6CBAF1 males and females were significantly heavier than controls after 4-6 months of treatment. To measure fecundity, B6CBAF1 males at an average age of 750 days were each caged with two young B6 females; 10 of 17 L-deprenyl-injected males sired an average of 31.3 pups per male, while 14 of 24 controls sired 82.1 pups per male.

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