Faculty Research 1990 - 1999

Title

The appearance of Thy-1- donor T cells in the peripheral circulation 3-6 weeks after bone marrow transplantation suggests an extrathymic origin.

Document Type

Article

Publication Date

1996

Keywords

Antigens-Thy-1, Biological-Markers, Bone-Marrow-Transplantation: im, Cell-Differentiation: im, Glucosephosphate-Isomerase, Lymphocyte-Count, Male, Mice, Mice-Inbred-C57BL, Mice-Mutant-Strains, Species-Specificity, Spleen: en, im, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocyte-Subsets: en, cl, tr

JAX Source

Int Immunol 1996 Feb;8(2):171-6

Grant

DK25687/DK/NIDDK, HL46536/HL/NHLBI, CA60055/CA/NCI

Abstract

Donor and host T cells were distinguished by T cell antigen marker Thy-1 isotype and cytoplasmic isozyme Gpi-1 in this study of bone marrow transplantation between congenic mice. During the first 3-6 weeks after irradiation and marrow transfer, percentages of cells bearing the donor Thy-1 isotype in the periphery are much lower than percentages of T cells bearing the donor Gpi-1 marker. Apparently a population of Thy-1- donor T cells exists for several weeks after bone marrow transplantation. Further study showed that this population of CD3+, Thy-1- donor T cells expressed CD4+ or CD8+ and was found in peripheral blood and spleen but not in the thymus. This finding suggests their extrathymic origin.

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