Faculty Research 1990 - 1999

Title

Chromosomal localization of a new mouse lens opacity gene (lop18).

Document Type

Article

Publication Date

1996

Keywords

Cataract: ge, pa, Chromosome-Mapping, Crosses-Genetic, Crystallins: ge, Female, Genes-Recessive: ge, H-2-Antigens: ge, Lens-Crystalline: pa, Male, Mice, Mice-Inbred-CBA, Mice-Inbred-C57BL, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genomics 1996 Aug 15;36(1):171-3

Abstract

Examination of mouse strains with a slit lamp and indirect ophthalmoscopy revealed that strain CBA/CaGnLe has a white cataract obvious at weaning age. It soon progresses to a large white nuclear cataract with mild cortical changes. Crosses with C57BL/6J showed that this is inherited as a single recessive fully penetrant gene, which we have designated lop18 (lens opacity 18). Linkage analysis using visible marker T (brachyury), histocompatibility marker H2, and microsatellite markers D17Mit21, D17Mit28, D17Mit38, and D17Mit46 shows that the lop18 gene is located, approximately 16 cM from the centromere on mouse Chromosome 17. It is a likely candidate mutation for the alpha-crystallin (Crya1) gene.