Faculty Research 1990 - 1999

Title

Location of the 9257 and ataxia mutations on mouse chromosome 18.

Document Type

Article

Publication Date

1996

Keywords

Ataxia: ge, Base-Sequence, Chromosome-Mapping, Linkage-(Genetics): ge, Mice, Mice-Inbred-C57BL, Mice-Inbred-DBA, Molecular-Sequence-Data, Mutation, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Transgenes: ge

JAX Source

Mamm Genome 1996 Jun;7(6):417-9

Grant

GM24872/GM/NIGMS, PR01183, T32DC00024/DC/NIDCD

Abstract

The location of three mutations on proximal Chromosome (Chr) 18 was determined by analysis of the offspring of several backcrosses. The results demonstrate that ataxia and the insertional mutation TgN9257Mm are separated by less than 1 cM and are located approximately 3 cM from the centromere, while the balding locus is 7 cM more distal. Previous data demonstrated that the twirler locus also maps within 1 cM of ataxia. The corrected locations will contribute to identification of appropriate candidate genes for these mutations. Two polymorphic microsatellite markers for proximal Chr 18 are described, D18Umi1 and D18Umi2. The Lama3 locus encoding the alpha 3 subunit of nicein was mapped distal to ataxia and did not recombine with Tg9257.

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