Faculty Research 1990 - 1999

Title

Effect of the mouse scid mutation on meiotic recombination.

Document Type

Article

Publication Date

1996

Keywords

Chromosome-Mapping, Crosses-Genetic, DNA-Satellite: an, ge, Female, Genetic-Markers, Genotype, Isoenzymes: an, ge, Linkage-(Genetics), Male, Meiosis, Mice, Mice-Inbred-BALB-C, Mice-Inbred-C57BL, Mice-SCID: ge, Polymerase-Chain-Reaction, Recombination-Genetic, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Mamm Genome 1996 Jul;7(7):497-500

Grant

RR01183/RR/NCRR, CA34196/CA/NCI, AI30389/AI/NIAID

Abstract

The goal of this study was to determine the effect of the mouse severe combined immunodeficiency (scid) mutation on the rate of meiotic recombination, by standard backcross linkage analysis. For this purpose, we examined four crosses that involved F1 hybrid animals heterozygous for the strain C57BL/6 and BALB/c genomes. In one set of reciprocal crosses, F1 animals were homozygous scid/scid, and in a second set of reciprocal crosses, F1 mice were homozygous wild-type (+/+) at the scid locus. Backcross progeny were typed for recombination between selected genetic markers on mouse Chromosomes (Chrs) 1, 4, 6, 7, 9, 15, and 17. Although some differences in recombination were observed over some intervals, the expression of the SCID phenotype did not appear to have a major or consistent effect on meiotic recombination.

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