Faculty Research 1990 - 1999

Title

Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome.

Document Type

Article

Publication Date

1996

Keywords

Antigens-CD: bi, ge, Cell-Adhesion-Molecules: ge, Disease-Progression, DNA-Complementary, Genetic-Markers, Genome, Human, Information-Systems, Melanoma: ge, pa, Mice, Mice-Inbred-C57BL, Muridae, Platelet-Membrane-Glycoproteins: bi, ge, Rats, Restriction-Mapping, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genomics 1996 Jul 15;35(2):389-91

Abstract

The membrane protein CD63, a molecular marker for early stages of melanoma progression, has been associated with platelet storage pool deficiency disorders (SPD). CD63 localizes to the membranes of platelets, lysosomes, and melanosomes, all of which are affected in a specific subgroup of SPD. The cDNA encoding CD63 detects two closely related sequences that map to different regions of the mouse genome. One locus maps to mouse Chromosome (Chr) 10 in a region that shares linkage homology with the human chromosome encoding human CD63. The second locus maps to mouse Chr 18 in a region that bears no known human CD63-related genes. No SPD has been localized to these regions of either the mouse or the human chromosomes.