Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo.
Animal, Base-Sequence, Blastocyst: cy, ph, Cell-Cycle, Cell-Cycle-Proteins: bi, Cloning-Molecular, Female, Fetal-Development, Gene-Expression-Regulation-Developmental, Genomic-Imprinting, Male, Mice, Mice-Inbred-Strains, Molecular-Sequence-Data, Multigene-Family, Oocytes: cy, ph, Ovary: cy, ph, Phosphoproteins: bi, Sequence-Homology-Amino-Acid, Spermatogenesis, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, Transcription-Genetic, Y-Chromosome, Zygote: cy, ph
Development 1997 Jan;124(2):493-503
Timely translation of maternal transcripts and post-translational modification of their gene products control the initial development of preimplantation-stage embryos. We have isolated and characterized a gene encoding a stage-specific embryonic protein. This novel gene, spindlin (Spin), is an abundant maternal transcript present in the unfertilized egg and 2-cell, but not 8-cell, stage embryo. Spin exhibits high homology to a multicopy gene, Y-linked spermiogenesis-specific transcript (Ssty), and together they form a new gene family expressed during gametogenesis. We find that spindlin associates with the meiotic spindle and is modified by phosphorylation in a cell-cycle-dependent fashion. Furthermore, it comigrates with the previously described 30x10(3) Mr metaphase complex which is posttranslationally modified during the first mitotic cell cycle. Our data suggest that spindlin plays a role in cell-cycle regulation during the transition from gamete to embryo.
Oh, B; Hwang, S Y.; Solter, D; and Knowles, B B., " Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo." (1997). Faculty Research 1990 - 1999. 844.
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